|Position in department||Research Group Coordinator (Molecular Medicine), Director of Essex Biomedical Sciences Institute, Director of MSc Molecular Medicine, Departmental Radiation Supervisor
|Staff position||Professor of Molecular Oncology
|E-mail||klenovae (non Essex users should add @essex.ac.uk)
|Telephone||4868 (non Essex users should add 01206-87 to the beginning of this number)
|Biography||I joined the Department of Biological Sciences in January 2001 as a Lecturer in Molecular Biology.
I graduated from the Moscow State University with the M.Sc. degree in Virology in 1982 and obtained my D.Phil. degree in Genetics at The Institute of General Genetics of the USSR Academy of Science in 1988.
My research experience:
1996 – 2000 - Departmental Lecturer at the Genetics Unit, Department of Biochemistry, University of Oxford.
1992 - 1996 - Fellow of the European Molecular Biology Organization (EMBO) and International Human Frontier Science Program ( HFSPO ) Long-Term Fellowships at the Institute of Cancer Research, London.
1989-1991 Senior Research Fellow, Institute of Carcinogenesis, All-Union Cancer Research Center, Moscow, USSR.
1982-1989 Junior Research Fellow, The Institute of General Genetics, All-Union Academy of Science, Moscow, USSR.
|Research interests|| My main research interests lie in the areas of regulation of transcription and molecular mechanisms of tumourigenesis.
We study the biological role of two related proteins, CTCF and BORIS, in genetics, epigenetics and disease, particularly, in tumourigenesis. CTCF and BORIS belong to a group of Zinc Finger transcription factors and share an identical DNA binding domain. Although related, CTCF and BORIS have different functions. CTCF has properties of a tumour suppressor, whereas BORIS has features of an oncogene. CTCF is present in various cell types, whereas BORIS normally is found only in the testis. Importantly, BORIS is activated in many cancers and could potentially be used as cancer biomarker.
My research projects have been funded by various granting bodies, which include Councils and Charities such as The Medical Research Council (MRC), The Wellcome Trust, BBSRC, Association for International Cancer Research, Breast Cancer Campaign, Association for International Cancer Research, Breast Cancer Research Trust, NHS and others.
I would be very interested to receive enquiries concerning research opportunities in my laboratory from D.Phil. students, Visiting and Post-Doctoral Scientists.
Dr Klenova's laboratory
|Publications||Link to publications for Elena Klenova